反应详情

A solution of 24.2 g. (0.10 mole) of benzyl N-hydroxymethylsuccinamate and 28.9 g. (0.11 mole) of triphenylphosphine in 500 ml. carbon tetrachloride is stirred at reflux for 12 hours. After filtering and washing the precipitate with benzene, the organic solvents are removed at 15 - 20 mm. and 30° - 40° C. to give benzyl N-chloromethylsuccinamate of sufficient purity for use in the next step.

1. temperatureat reflux for 12 hours
2. filtrationAfter filtering
3. washwashing the precipitate with benzene
4. customthe organic solvents are removed at 15 - 20 mm