HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → 1-(4-Hydroxyphenyl)-3-(4-bromophenyl)-2-phenyl-2-propen-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-Bromobenzaldehyde | HCID 70741 | — |
| Reactant | Benzyl 4-hydroxyphenyl ketone | HCID 75607 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(4-Hydroxyphenyl)-3-(4-bromophenyl)-2-phenyl-2-propen-1-one | HCID 54410820 | 51% |
Reaction Steps
8.02 g (0.0378 mole) of 1-(4-hydroxyphenyl)-2-phenylethanone, 7.0 g (0.0378 mole) of 4-bromobenzaldehyde, 3.01 g (0.0353 mole) of piperidine and 16.5 ml of methanol was treated or mentioned under Example IA to give 13 g (74%) of crude product. 12.5 g (0.027 mole) of this phenol was refluxed with 120 ml and worked up as in Example IB. Recrystallization from methanol gave 5.2 g (51%) of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04038415 |
| Source dataset | uspto-grants-1977_07 |
| ORD ID | ord-59cd9cb00f1e40dbbc8499b363528a3b |
| Source note | uspto-grants-1977_07 |