Hydrochloric Acid → HCID 22402921, compound

HRID 259675Notes

Reaction equation

HRID 259675 reaction equation
Cl.[F:2][C:3]1[CH:15]=[CH:14][C:6]2[C:7]([CH2:10][C:11]([OH:13])=[O:12])=[N:8][O:9][C:5]=2[CH:4]=1.[CH2:16](Cl)Cl>CO>[F:2][C:3]1[CH:15]=[CH:14][C:6]2[C:7]([CH2:10][C:11]([O:13][CH3:16])=[O:12])=[N:8][O:9][C:5]=2[CH:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 15562922HCID 15562922, compound

Product 1

HCID 22402921HCID 22402921, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Hydrogen chloride gas is bubbled into a cold (ice/water bath) solution of 6-fluoro-1,2-benzisoxazole-3-acetic acid (13.7 g, 0.0702 mol) in methanol over a 15 minute period. The reaction mixture is concentrated in vacuo to obtain a brown-orange solid. Flash column chromatography of the solid using silica gel and methylene chloride gives the title product as a white solid, mp 60°-61° C.

Workup

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. customto obtain a brown-orange solid

Sources & evidence

ORD record
ord-8b49f35f2d7c4101a8eddce40e8e3b4c
Source dataset
uspto-grants-1996_06
Patent number
US05523278

Reaction notes

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