Hydrochloric Acid → HCID 178432185, compound

HRID 259706Notes

Reaction equation

[CH3:1][C:2]1[NH:3][C:4]2[C:5](=[CH:7][CH:8]=[C:9]([C:15]([O:17]C)=[O:16])[C:10]=2[C:11]([O:13]C)=[O:12])[N:6]=1.[OH-].[Na+].Cl>>[CH3:1][C:2]1[NH:3][C:4]2[C:5](=[CH:7][CH:8]=[C:9]([C:15]([OH:17])=[O:16])[C:10]=2[C:11]([OH:13])=[O:12])[N:6]=1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 14798Sodium Hydroxide

HCID 178497326HCID 178497326, compound

Product 1

HCID 178432185HCID 178432185, compound

Conditions

Temperature: 70 °C

Procedure

A mixture of dimethyl 2-methyl-4,5-benzimidazoledicarboxylate and 8 equivalents of 10N sodium hydroxide is stirred 4 hours at 70° C., cooled and acidified with hydrochloric acid to afford the title product as cream-colored crystals, mp 270° C. (dec).

Workup

temperaturecooled

Sources & evidence

ORD record: ord-82da21a90d21432780864b6187dbae0b
Source dataset: uspto-grants-1996_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05523279

Reaction notes

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