反应详情

Methyl 2-bromopropionate (60.12 g, 0.36 mol) is added to a mixture of 4-nitrophenol (25 g, 0.18 mol) and potassium carbonate (49.75 g, 0.36 mol) in acetonitrile. The reaction mixture is refluxed for 18 hours, cooled and poured into water. The phases are separated and the aqueous phase is extracted with ethyl acetate. The organic phase and the organic extracts are combined, washed with water, dried over anhydrous sodium sulfate and concentrated in vacuo to give the title product as a white powder, mp 79°-80° C.

1. temperatureThe reaction mixture is refluxed for 18 hours
2. temperaturecooled
3. customThe phases are separated
4. extractionthe aqueous phase is extracted with ethyl acetate
5. washwashed with water
6. dry with materialdried over anhydrous sodium sulfate
7. concentrationconcentrated in vacuo