Morpholine → HCID 531871, compound

HRID 259770Notes

Reaction equation

HRID 259770 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH2:7]([C:9]1[CH:17]=[CH:16][C:12]([C:13](Cl)=[O:14])=[CH:11][CH:10]=1)[CH3:8]>C(Cl)Cl>[CH2:7]([C:9]1[CH:17]=[CH:16][C:12]([C:13]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[O:14])=[CH:11][CH:10]=1)[CH3:8]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 853684-Ethylbenzoyl chloride

Product 1

HCID 531871HCID 531871, compoundYield 96.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a cooled solution of 9.6 g (0.11 mole) of morpholine in 25 ml methylene chloride is added 8.4 g (0.05 mole) of 4-ethylbenzoyl chloride dropwise. The reaction is stirred 30 minutes and a white precipitate formed. The mixture is washed three times each with 25 ml of water, dried over anhydrous magnesium sulfate and evaporated in vacuo to yield 10.6 g of yellow oil.

Workup

  1. customa white precipitate formed
  2. washThe mixture is washed three times each with 25 ml of water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-cb4cfa8b72e240b3873f9a45f4650b03
Source dataset
uspto-grants-1996_06
Patent number
US05523325

Reaction notes

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