HRID259776

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

HCID7189

Chalcone

C15H12O

结构：CCOC(=O)c1cc(/C=C/C(=O)c2cccc(OCCN)c2)ccc1OCC(=O)O.O=C([O-])C(F)(F)F

HCID86749527

未命名化合物

PRODUCTS

生成物

结构：C=CCOc1ccc(OCCN)cc1C(=O)/C=C/c1ccc(OCC(=O)O)c(C(=O)OCC)c1.O=C([O-])C(F)(F)F

HCID86749526

未命名化合物

收率 76%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Chalcone 3e was deprotected using trifluoroacetic acid in CH2Cl2 as described for 2f to yield a yellow solid (76%). HR-MS: Calc'd. 470.1815, Found 470.1810.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-196caa185cbb41f4912aebf6ba276978
来源数据集: uspto-grants-1996_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05523302
来源说明: uspto-grants-1996_06

反应 SMILES

C1([CH:7]=[CH:8][C:9](C2C=CC=CC=2)=[O:10])C=CC=CC=1.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[NH2:24][CH2:25][CH2:26][O:27][C:28]1[CH:29]=[C:30]([C:34](=[O:53])/[CH:35]=[CH:36]/[C:37]2[CH:38]=[CH:39][C:40]([O:48][CH2:49][C:50]([OH:52])=[O:51])=[C:41]([CH:47]=2)[C:42]([O:44][CH2:45][CH3:46])=[O:43])[CH:31]=[CH:32][CH:33]=1.FC(F)(F)C([O-])=O>C(Cl)Cl>[CH2:9]([O:10][C:31]1[CH:32]=[CH:33][C:28]([O:27][CH2:26][CH2:25][NH2:24])=[CH:29][C:30]=1[C:34](=[O:53])/[CH:35]=[CH:36]/[C:37]1[CH:38]=[CH:39][C:40]([O:48][CH2:49][C:50]([OH:52])=[O:51])=[C:41]([CH:47]=1)[C:42]([O:44][CH2:45][CH3:46])=[O:43])[CH:8]=[CH2:7].[F:17][C:18]([F:23])([F:22])[C:19]([O-:21])=[O:20]