Trifluoroacetic acid → HCID 86749526, compound

HRID 259776Notes

Reaction equation

HRID 259776 reaction equation
C1([CH:7]=[CH:8][C:9](C2C=CC=CC=2)=[O:10])C=CC=CC=1.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[NH2:24][CH2:25][CH2:26][O:27][C:28]1[CH:29]=[C:30]([C:34](=[O:53])/[CH:35]=[CH:36]/[C:37]2[CH:38]=[CH:39][C:40]([O:48][CH2:49][C:50]([OH:52])=[O:51])=[C:41]([CH:47]=2)[C:42]([O:44][CH2:45][CH3:46])=[O:43])[CH:31]=[CH:32][CH:33]=1.FC(F)(F)C([O-])=O>C(Cl)Cl>[CH2:9]([O:10][C:31]1[CH:32]=[CH:33][C:28]([O:27][CH2:26][CH2:25][NH2:24])=[CH:29][C:30]=1[C:34](=[O:53])/[CH:35]=[CH:36]/[C:37]1[CH:38]=[CH:39][C:40]([O:48][CH2:49][C:50]([OH:52])=[O:51])=[C:41]([CH:47]=1)[C:42]([O:44][CH2:45][CH3:46])=[O:43])[CH:8]=[CH2:7].[F:17][C:18]([F:23])([F:22])[C:19]([O-:21])=[O:20]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7189CinnamoylbenzeneHCID 86749527HCID 86749527, compound

Product 1

HCID 86749526HCID 86749526, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Chalcone 3e was deprotected using trifluoroacetic acid in CH2Cl2 as described for 2f to yield a yellow solid (76%). HR-MS: Calc'd. 470.1815, Found 470.1810.

Sources & evidence

ORD record
ord-196caa185cbb41f4912aebf6ba276978
Source dataset
uspto-grants-1996_06
Patent number
US05523302

Reaction notes

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