反应详情

Nitrile 91a (4.8 g, 27 mmol) was hydrogenated on a Parr shaker at 40 psi H2 in the presence of 10% Pd/C (0.48 g) and p-toluenesulfonic acid (5.2 g, 27 mmol) in methanol (100 mL). The solution was filtered through a Celite pad to remove the catalyst, then solvent was removed in vacuo to give an orange solid (10.7 g). HR-MS: Calc'd. 180.1025. Found 180.1025.

1. filtrationThe solution was filtered through a Celite pad
2. customto remove the catalyst
3. customsolvent was removed in vacuo