HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Methyl 3-amino-2-chloro-2-pentenoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methyl 2-chloro-3-oxopentanoate | HCID 545096 | — |
| Product | Methyl 3-amino-2-chloro-2-pentenoate | HCID 86749529 | 80% |
Reaction Steps
Dry NH3 gas is passed through 48.9 g (0.30 mol) of methyl 2-chloro-3-oxovalerate at 70° C. for a period of 2 h. After removal of volatile constituents in vacuo, the crude product is dissolved in diisopropyl ether and washed with a little ice water. After drying over MgSO4, the solvent is removed in vacuo. Yield: 80.0% [GC]
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05523404 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-91b8db3807ed4581804a94979f1315e2 |
| Source note | uspto-grants-1996_06 |