Methyl 2-chloroacetoacetate → Methyl 3-amino-2-chloro-2-butenoate

HRID 259801Notes

Reaction equation

HRID 259801 reaction equation
[Cl:1][CH:2]([C:7]([CH3:9])=O)[C:3]([O:5][CH3:6])=[O:4].C([O-])(=O)C.[NH4+:14]>CO>[NH2:14][C:7]([CH3:9])=[C:2]([Cl:1])[C:3]([O:5][CH3:6])=[O:4]

Participants

4

Reactant 2

HCID 107332Methyl 2-chloroacetoacetateHCID 517165Ammonium Acetate

Product 1

HCID 76224675Methyl 3-amino-2-chloro-2-butenoateYield 63.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

50 g (0.33 mol) of methyl 2-chloroacetoacetate are reacted with 64 g (0.83 mol) of ammonium acetate in 100 ml of methanol and worked up in analogy to Example 2. Yield: 63.9% [GC]

Sources & evidence

ORD record
ord-a4e4aeabb417434fb462652a54b6fdbb
Source dataset
uspto-grants-1996_06
Patent number
US05523404

Reaction notes

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