Formamide → HCID 178440190, compound

HRID 259809Notes

Reaction equation

HRID 259809 reaction equation
[NH2:1][C:2]([CH:10]([CH3:12])[CH3:11])=[C:3]([Cl:9])[C:4](OCC)=[O:5].[CH:13]([NH2:15])=O.C[O-].[Na+]>CO>[Cl:9][C:3]1[C:4]([OH:5])=[N:15][CH:13]=[N:1][C:2]=1[CH:10]([CH3:12])[CH3:11]

Participants

5

Reactant 3

HCID 713FormamideHCID 10942334Sodium MethoxideHCID 86749531Ethyl 3-amino-2-chloro-4-methyl-2-pentenoate

Product 1

HCID 178440190HCID 178440190, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

45.1 g (0.24 mol) of ethyl 3-amino-2-chloro-4-methyl-2-pentenoate are reacted with 36.8 g (0.59 mol) of formamide and 109 ml of sodium methylate solution in 130 ml of methanol and worked up in analogy to Example 9. Yield: 34.5 g (83.3%)

Sources & evidence

ORD record
ord-86673681deba450884fd73d84e02cc07
Source dataset
uspto-grants-1996_06
Patent number
US05523404

Reaction notes

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