反应详情

2(S)-(N,N-Dibenzylamino)-1-cyclohexyl-3(S)-hydroxy-6-methylheptane (5 g) was dissolved in methanol (50 ml). Ammonium formate (6.18 g) and then 10% palladium-carbon (50% wet, 0.5 g) were added thereto, and the mixture was vigorously stirred at room temperature. After the completion of the reaction, the reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. Ethyl acetate and water were added to the concentrated residue for extraction. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 4.13 g of 2(S)-amino-1-cyclohexyl-3(S)-hydroxy-6-methylheptane.

1. customAfter the completion of the reaction
2. filtrationthe reaction mixture was filtered
3. concentrationthe filtrate was concentrated under reduced pressure
4. additionEthyl acetate and water were added to the concentrated residue for extraction
5. washThe organic layer was washed with saturated brine
6. dry with materialdried over anhydrous magnesium sulfate
7. customThe solvent was evaporated under reduced pressure