反应详情

5.8 parts of freshly distilled 3-carbomethoxypropionaldehyde in 10 parts of sodium-dried dioxan was added to a suspension of 12.4 parts benzhydrylammonium hypophosphite in 60 parts of sodium-dried dioxan at 100° and under nitrogen over 15 minutes. 40 Parts water/dioxan was removed by distillation during the addition such that the temperature remained at 100° or above. The resulting clear solution was cooled and diluted with an equal volume of alcohol to give DL-1-benzhydrylamino-3-carbomethoxypropanephosphonous acid, melting point 162°-164°.

1. custom40 Parts water/dioxan was removed by distillation during the addition such that the temperature
2. customremained at 100° or above
3. temperatureThe resulting clear solution was cooled
4. additiondiluted with an equal volume of alcohol