関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Fluoro-5-methoxybenzoic acid | HCID 2774543 | — |
| 溶媒 | Hydrogen Bromide | HCID 260 | — |
| 生成物 | 2-Fluoro-5-hydroxybenzoic acid | HCID 2774480 | — |
反応手順
6-Fluoro-3-methoxybenzoic acid (500 mg, 2.94 mmol) was mixed with freshly distilled 48% HBr (20 mL) and heated at 100° C. for 14 h. Water and HBr were evaporated and the crude product (462 mg) was used without further purification. 1H NMR(CD3OD): δ7.28-7,29 (m, 1H), 6.92-7.12 (m, 2H); 13C NMR (CD3OD): δ167.80, 157.26 (d, J=249 Hz), 154.77, 122.52 (d, J=10.4 Hz), 120.49 (d, J=11 Hz), 118.77 (d, J=19 Hz), 118.58.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05523475 |
|---|
| 出典データセット | uspto-grants-1996_06 |
|---|
| ORD ID | ord-2b17b083510b4baca035fa35dd56b075 |
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| 出典メモ | uspto-grants-1996_06 |
|---|
