反应详情

温度

100 °C

6-Fluoro-3-methoxybenzoic acid (500 mg, 2.94 mmol) was mixed with freshly distilled 48% HBr (20 mL) and heated at 100° C. for 14 h. Water and HBr were evaporated and the crude product (462 mg) was used without further purification. 1H NMR(CD3OD): δ7.28-7,29 (m, 1H), 6.92-7.12 (m, 2H); 13C NMR (CD3OD): δ167.80, 157.26 (d, J=249 Hz), 154.77, 122.52 (d, J=10.4 Hz), 120.49 (d, J=11 Hz), 118.77 (d, J=19 Hz), 118.58.

1. customWater and HBr were evaporated
2. customthe crude product (462 mg) was used without further purification