反应详情

40.00 Grams of 2-chloroallylphenylcarbinol were dissolved in 400 g of dimethylformamide, and 36.85 g of potassium hydroxide in a flake form were added. The mixture was stirred at room temperature for 2 hours and then neutralized with a 20% acetic acid aqueous solution. The resultant mixture was subjected to extraction with toluene. The toluene phase was washed with water and then dried over magnesium sulfate. The desiccant was filtered off, and the toluene was distilled off under reduced pressure to give 31.35 g of phenylpropargylcarbinol, nD20 =1.546, FI-MS m/e 146 (M+), propargyl compound/allene compound=92.3/7.7.

1. extractionThe resultant mixture was subjected to extraction with toluene
2. washThe toluene phase was washed with water
3. dry with materialdried over magnesium sulfate
4. filtrationThe desiccant was filtered off
5. distillationthe toluene was distilled off under reduced pressure