HCID 20322477, compound → HCID 21325983, compound

HRID 26013Notes

Reaction equation

HRID 26013 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([C:8]2[CH:9]=[C:10]([CH2:14][C:15](Cl)=[O:16])[CH:11]=[CH:12][CH:13]=2)=[O:7])=[CH:4][CH:3]=1.[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([N:27]2[CH2:32][CH2:31][N:30]([CH:33](O)[CH3:34])[CH2:29][CH2:28]2)=[CH:23][CH:22]=1.C1C=CC=CC=1.C(OCC)(=[O:44])C.C(N(CC)CC)C>>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([C:8]2[CH:9]=[C:10]([CH2:14][C:15]([O:44][CH2:34][CH2:33][N:30]3[CH2:31][CH2:32][N:27]([C:24]4[CH:25]=[CH:26][C:21]([Cl:20])=[CH:22][CH:23]=4)[CH2:28][CH2:29]3)=[O:16])[CH:11]=[CH:12][CH:13]=2)=[O:7])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 20322477HCID 20322477, compoundHCID 539017064-(4Chlorophenyl)-1-piperazinyl-ethanolHCID 542455913-(4-Chlorobenzoyl)-benzeneacetic acid chloride

Product 1

HCID 21325983HCID 21325983, compound

Procedure

Using the procedure of Example 2, 3-(4-chlorobenzoyl)-benzeneacetic acid chloride was reacted with 4-(4chlorophenyl)-1-piperazinyl-ethanol to obtain 2-[4-(4-chlorophenyl)-1-piperazinyl]-ethyl 3-(4-chlorobenzoyl)-benzeneacetate with an Rf=0.68 (9-1-0.05 benzene-ethyl acetate-triethylamine eluant). Treatment with hydrochloric acid resulted in the formation of the hydrochloride salt melting at 142° C.

Sources & evidence

ORD record
ord-e4c2d7d7e62341cbbaba76a23b2d8d9c
Source dataset
uspto-grants-1979_04
Patent number
US04147790

Reaction notes

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