反应详情

To a solution of 10 mg of sodium in 50 mL of anhydrous methanol was added 0.632 g (1 mmol) of 4-amino-2-phenyl-8-[2-deoxy-3,5-di-O-(4-chlorophenyl)-βD-ribofuranosyl]pteridine-7-one (4). The solution was stirred at room temperature for 1 hour. The solution was then neutralized by the addition of AcOH and then evaporated. The residue was re, crystallized from methanol/H2O to give 5 as 0.323 g (91% yield) of colorless crystals (m.p. 169°-172° C.).

1. customevaporated
2. customcrystallized from methanol/H2O