Benzyl Alcohol → HCID 10130617, compound

HRID 260146Notes

Reaction equation

HRID 260146 reaction equation
[Na].Cl[C:3]1[N:8]=[C:7]([NH2:9])[N:6]=[C:5]([NH2:10])[CH:4]=1.[CH2:11]([OH:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[NH2:9][C:7]1[N:6]=[C:5]([NH2:10])[CH:4]=[C:3]([O:18][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:8]=1

Participants

4

Reactant 3

HCID 244Benzyl AlcoholHCID 674322,4-Diamino-6-chloropyrimidineHCID 5360545Sodium

Product 1

HCID 10130617HCID 10130617, compound

Procedure

A solution of 3.8 g sodium in 100 mL benzylalcohol is heated in an oil bath with 21.6 g 6-chloro-2,4-diamino-pyrimidine (6) for 3 hours at 160° C. The surplus alcohol is distilled off in vacuum.

Workup

  1. distillationThe surplus alcohol is distilled off in vacuum

Sources & evidence

ORD record
ord-f165397cf4cc4a819efc903e863fcc7a
Source dataset
uspto-grants-1996_06
Patent number
US05525711

Reaction notes

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