Glutaric anhydride → HCID 22861973, compound

HRID 260257Notes

Reaction equation

[C:1]1(=[O:8])[O:7][C:5](=[O:6])[CH2:4][CH2:3][CH2:2]1.[CH3:9][O:10][C:11](=[O:46])[C@H:12]([CH2:27][C:28]1[CH:35]=[C:33]([I:34])[C:32]([O:36][C:37]2[CH:44]=[C:42]([I:43])[C:41]([OH:45])=[C:39]([I:40])[CH:38]=2)=[C:30]([I:31])[CH:29]=1)[NH:13][C:14](=[O:26])[CH2:15][CH2:16][CH2:17][C:18]([N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)=[O:19]>>[CH3:9][O:10][C:11](=[O:46])[C@H:12]([CH2:27][C:28]1[CH:35]=[C:33]([I:34])[C:32]([O:36][C:37]2[CH:44]=[C:42]([I:43])[C:41]([OH:45])=[C:39]([I:40])[CH:38]=2)=[C:30]([I:31])[CH:29]=1)[NH:13][C:14](=[O:26])[CH2:15][CH2:16][CH2:17][C:18]([N:20]1[CH2:25][CH2:24][N:23]([C:5](=[O:6])[CH2:4][CH2:3][CH2:2][C:1]([OH:7])=[O:8])[CH2:22][CH2:21]1)=[O:19]

Participants

Reactant 2

HCID 7940Glutaric anhydride

HCID 22861978HCID 22861978, compound

Product 1

HCID 22861973HCID 22861973, compound

Procedure

This material was prepared using the procedure outlined in Intermediate Preparation 1, step 6 except glutaric anhydride was reacted with N-(4-piperazinocarbonylbutyryl)thyroxine methyl ester hydromide from step 4. This compound was purified by column chromatography (SiO2).

Workup

customThis material was prepared
customThis compound was purified by column chromatography (SiO2)

Sources & evidence

ORD record: ord-33853c55ea364fde9b24dff330aaddda
Source dataset: uspto-grants-1996_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05527709

Reaction notes

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