反应详情

To a cold (0° C.) solution of methylene chloride (30 ml) containing 2(R)-hydroxy-1(S)-aminoindane (750 mg, 5.0 mmol) and triethylamine (606 mg, 6.0 mmol) was added a solution of hydrocinnamoyl chloride (843 mg, 5.0 mmol) in 5 ml of methylene chloride. After 2 hr the reaction was poured into a separatory funnel containing 50 ml of methylene chloride and washed with 10% citric acid solution (2×30 ml). The organic layer was dried, filtered and concentrated to afford a white solid.

1. additionAfter 2 hr the reaction was poured into a separatory funnel
2. washwashed with 10% citric acid solution (2×30 ml)
3. customThe organic layer was dried
4. filtrationfiltered
5. concentrationconcentrated
6. customto afford a white solid