3-Chloropropionyl chloride → 3-Chloro-1-(2-oxo-1,2,2a,3,4,5-hexahydrobenz[cd]indol-6-yl)-1-propanone

HRID 260293Notes

Reaction equation

HRID 260293 reaction equation
[NH:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]3[CH2:10][CH2:11][CH2:12][CH:3]([C:4]=23)[C:2]1=[O:13].[Cl:14][CH2:15][CH2:16][C:17](Cl)=[O:18]>>[Cl:14][CH2:15][CH2:16][C:17]([C:6]1[CH:7]=[CH:8][C:9]2[NH:1][C:2](=[O:13])[CH:3]3[CH2:12][CH2:11][CH2:10][C:5]=1[C:4]=23)=[O:18]

Participants

3

Reactant 2

HCID 693643-Chloropropionyl chlorideHCID 5993752a,3,4,5-Tetrahydrobenzo[cd]indol-2(1H)-one

Product 1

HCID 152969443-Chloro-1-(2-oxo-1,2,2a,3,4,5-hexahydrobenz[cd]indol-6-yl)-1-propanone

Procedure

Using 2a,3,4,5-tetrahydrobenz[cd]indol-2(1H)-one and 3-chloropropionyl chloride, the same procedure as in Reference Example 2 was followed, to yield the title compound as a colorless needle crystal having a melting point of 175° to 178° C.

Sources & evidence

ORD record
ord-3fb41dddd3f649798c7ec5da91331f3d
Source dataset
uspto-grants-1996_06
Patent number
US05527800

Reaction notes

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