HCID 11048495, compound → HCID 15293075, compound

HRID 260301Notes

Reaction equation

HRID 260301 reaction equation
[CH2:1]([Mg]Br)[CH:2]=[CH2:3].C([O:9][CH:10]1[CH2:34][CH2:33][C@@:32]2([CH3:35])[C:12](=[CH:13][C:14](=[O:37])[C@@H:15]3[C@@H:31]2[CH2:30][CH2:29][C@@:28]2([CH3:36])[C@H:16]3[CH2:17][CH2:18][C@@H:19]2[C@H:20]([CH3:27])[CH2:21][CH2:22][CH2:23][CH:24]([CH3:26])[CH3:25])[CH2:11]1)(=O)C>C1COCC1>[CH2:3]([C:14]1([OH:37])[CH:13]=[C:12]2[C@:32]([CH3:35])([CH2:33][CH2:34][CH:10]([OH:9])[CH2:11]2)[C@@H:31]2[C@@H:15]1[C@H:16]1[C@:28]([CH3:36])([CH2:29][CH2:30]2)[C@@H:19]([C@H:20]([CH3:27])[CH2:21][CH2:22][CH2:23][CH:24]([CH3:25])[CH3:26])[CH2:18][CH2:17]1)[CH:2]=[CH2:1]

Participants

4

Reactant 2

HCID 11048495HCID 11048495, compoundHCID 178455850HCID 178455850, compound

Product 1

HCID 15293075HCID 15293075, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following the analogous general Grignard procedure of Example 2, allyl magnesium bromide was reacted with Compound 1 in dry THF to yield the titled product 11. Proton NMR confirmed the assigned structure.

Sources & evidence

ORD record
ord-a83b0fc3898142c2b5abe225f441d21b
Source dataset
uspto-grants-1996_06
Patent number
US05527807

Reaction notes

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