反应详情

3-(3-Aminophenyl)propionic acid (1 g, 6.06 mM) was dissolved in allyl alcohol (25 ml), and toluene-4-sulfonic acid (1.21 g, 6.36 mM) added. The mixture was heated to reflux, the distillate being passed through 3 Å molecular sieves, for 24 hours. After neutralisation of the mixture with triethylamine, the solvent was removed, the residue dissolved in ethyl acetate, and washed with water, aqueous NaHCO3, brine, and dried (MgSO4), to give title compound.

1. temperatureThe mixture was heated
2. temperatureto reflux
3. customAfter neutralisation of the mixture with triethylamine, the solvent was removed
4. dissolutionthe residue dissolved in ethyl acetate
5. washwashed with water, aqueous NaHCO3, brine
6. dry with materialdried (MgSO4)