反应详情

Dimethyl 2-vinylglutamate hydrochloride (570 mg, 2 mM), is treated with saturated aqueous sodium carbonate (20 ml) and the resulting mixture extracted with dichloromethane. The organic phase is dried and concentrated to afford the free base which is dissolved in 2-methoxyethanol (20 ml) and heated under reflux for 2 hours. The solvent is then removed in vacuo to afford 5-methoxycarbonyl-5-vinyl-2-pyrrolidone.

1. extractionthe resulting mixture extracted with dichloromethane
2. customThe organic phase is dried
3. concentrationconcentrated
4. customto afford the free base which
5. temperatureheated
6. temperatureunder reflux for 2 hours
7. customThe solvent is then removed in vacuo