Sodium Carbonate → HCID 21326425, compound

Participants

Reaction Steps

Dimethyl 2-vinylglutamate hydrochloride (570 mg, 2 mM), is treated with saturated aqueous sodium carbonate (20 ml) and the resulting mixture extracted with dichloromethane. The organic phase is dried and concentrated to afford the free base which is dissolved in 2-methoxyethanol (20 ml) and heated under reflux for 2 hours. The solvent is then removed in vacuo to afford 5-methoxycarbonyl-5-vinyl-2-pyrrolidone.

Provenance & Evidence