反应详情

温度

60 °C

97.2 g of 4-hydroxycoumarin and 69.3 g of ammonium acetate in 300 ml of ethylene glycol are heated to 70° C. for 3 hours, whilst stirring, and to 160° C. for 6 hours, the mixture is cooled to 60° C., 1 liter of water is added, whilst stirring, and the mixture is cooled to room temperature. The colourless crystalline precipitate is filtered off, washed with water and dried in vacuo at 60° C. 96 g of 4-aminocoumarin in an almost pure form are obtained

1. stirringwhilst stirring
2. temperaturethe mixture is cooled to room temperature
3. filtrationThe colourless crystalline precipitate is filtered off
4. washwashed with water
5. customdried in vacuo at 60° C