反应详情

To a solution of 5-fluoro-3-[1-hydroxy-1-(thiazol-2-yl)propyl](O-benzyl)phenol (200 mg, 0.58 mmol) in MeOH (9 mL) was added 10% Pd on charcoal (200 mg) and ammonium formate (180 mg, 2.9 mmol). The reaction mixture was refluxed for 2 h and then filtrated through a pad of celite and washed with EtOAc. After evaporation of the solvent, the residue was purified by chromatography on silica gel using a mixture of hexane:EtOAc 7:3 to give 116 mg (79%) of the title compound.

1. temperatureThe reaction mixture was refluxed for 2 h
2. filtrationfiltrated through a pad of celite
3. washwashed with EtOAc
4. customAfter evaporation of the solvent
5. customthe residue was purified by chromatography on silica gel using
6. additiona mixture of hexane:EtOAc 7:3