反应详情

温度

165 °C

To 50 g (0.33 mol) of 3-acetoxytoluene from Step 1 was added AlCl3 (60 g, 0.45 mol) and the resulting mixture was heated at 165° C. for 20 min., then cooled at 0° C. and HCl 1N was carefully added followed by Et2O. The aqueous phase was extracted 5× with Et2O and the combined organic phase wash washed with brine, dried over MgSO4 and evaporated. The residue was distilled under vacuum to give 42.2 (84%.) of the title compound.

1. temperaturecooled at 0° C.
2. extractionThe aqueous phase was extracted 5× with Et2O
3. washthe combined organic phase wash
4. washwashed with brine
5. dry with materialdried over MgSO4
6. customevaporated
7. distillationThe residue was distilled under vacuum