3-Furoic acid → HCID 10487090, compound

HRID 260466Notes

Reaction equation

HRID 260466 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]([OH:8])=O)=[CH:2]1.Cl.Cl.[CH3:11][NH:12][O:13][CH3:14].F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1>>[CH3:14][O:13][N:12]([CH3:11])[C:6]([C:3]1[CH:4]=[CH:5][O:1][CH:2]=1)=[O:8]

Participants

4

Reactant 3

HCID 102683-Furoic acidHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 18768729HCID 18768729, compound

Product 1

HCID 10487090HCID 10487090, compound

Procedure

The title compound was prepared from furan-3-carboxylic acid (3.4 g, 0.030 mol), N,O-dimethylhydroxylamine hydrochloride hydrochloride (2.9 g, 0.030 mol) triethylamine (8.3 mL, 0.060 mol) and benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorphosphate (13.3 g, 0.030 mol) according to the general procedure described in Example 1 for N-(3-pyridylmethyl)-5-chloro-3-phenylthio-2-carboxamide. NMR (DMSO-d6) δ8.25 (1H, s), 7.75 (1H, s), 3.70 (3H, s), 3.22 (3H, s).

Sources & evidence

ORD record
ord-78fea008a4e8446c992ad7cc8e014f5c
Source dataset
uspto-grants-1996_06
Patent number
US05527819

Reaction notes

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