HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 260479Generated: October 30, 2026
Ammonium Chloride → 3-Benzenesulfonyl-5-chloroindole-2-carboxamide
https://huagongshe.com/reaction/260479
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Ethyl 3-phenylsulfonyl-5-chloroindole-2-carboxylate | HCID 22401503 | — |
| Solvent | Ammonium Hydroxide | HCID 14923 | — |
| Product | 3-Benzenesulfonyl-5-chloroindole-2-carboxamide | HCID 454844 | — |
Reaction Steps
A suspension of ethyl 3-phenylsulfonyl-5-chloroindole-2-carboxylate (596 mg, 1.64 mmol) in aqueous conc. ammonium hydroxide (10 mL) containing ammonium chloride (28 mg) was heated at 100° C. for 3 hours in a sealed screw-top tube. The sealed tube was cooled in an ice bath as product crystallized out. The product was collected by filtration, rinsed with ice water, and dried to give the product, mp 253°-254° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05527819 |
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| Source dataset | uspto-grants-1996_06 |
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| ORD ID | ord-1938ad879d994b299f62cfe8700855bb |
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| Source note | uspto-grants-1996_06 |
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