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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 260494Generated: October 30, 2026

3-Benzenesulfonyl-5-chloroindole-2-carboxamide → 5-chloro-3-(phenylsulfonyl)-1H-Indole-2-carbonitrile

https://huagongshe.com/reaction/260494

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Benzenesulfonyl-5-chloroindole-2-carboxamideHCID 454844—
ReactantMethyl (carboxysulfamoyl)triethylammonium hydroxideHCID 86749577—
SolventTetrahydrofuranHCID 8028—
Product5-chloro-3-(phenylsulfonyl)-1H-Indole-2-carbonitrileHCID 22401514—

Reaction Steps

5-Chloro-3-phenylsulfonylindole-2-carboxamide reacts with methyl (carboxysulfamoyl)triethylammonium hydroxide inner salt (Burgess reagent) in tetrahydrofuran (THF) solvent as described by D. A. Claremon and B. T. Phillips (Tetrahedron Lett., 29, 2155 (1988)) to provide the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05527819
Source datasetuspto-grants-1996_06
ORD IDord-0b1fe20c76aa419b99e691b77546a0e6
Source noteuspto-grants-1996_06