HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanamide → 3-(benzenesulfonyl)-5-chloro-N'-cyano-1H-indole-2-carboxamidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanamide | HCID 9864 | — |
| Reactant | Ethyl 5-chloro-3-phenylsulfonylindole-2-carboximidate | HCID 135761968 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(benzenesulfonyl)-5-chloro-N'-cyano-1H-indole-2-carboxamidine | HCID 178512305 | — |
Reaction Steps
Ethyl 5-chloro-3-phenylsulfonylindole-2-carboximidate is reacted with an equimolar amount of cyanamide in absolute methanol (according to the procedure of K. R. Huffman and F. C. Schaefer (J. Org. Chem., 28, 1812 (1963)). After 30-60 minutes the solvent is removed and the residue purified by silica gel chromatography to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05527819 |
| Source dataset | uspto-grants-1996_06 |
| ORD ID | ord-137b4c1d36df4ac9a6d032cd522cafed |
| Source note | uspto-grants-1996_06 |