HCID 22401680, compound → HCID 22401691, compound

HRID 260516Notes

Reaction equation

HRID 260516 reaction equation
C([O:5][C:6]([CH2:8][N:9]1[C:13]2[N:14]=[C:15]3[S:21][CH2:20][CH2:19][N:16]3[C:17](=[O:18])[C:12]=2[CH:11]=[N:10]1)=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[C:6]([CH2:8][N:9]1[C:13]2[N:14]=[C:15]3[S:21][CH2:20][CH2:19][N:16]3[C:17](=[O:18])[C:12]=2[CH:11]=[N:10]1)([OH:7])=[O:5]

Participants

3

Reactant 1

HCID 22401680HCID 22401680, compound

Product 1

HCID 22401691HCID 22401691, compoundYield 63.1%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

In 30 ml of trifluoroacetic acid was dissolved 1.18 g (3.83 mmol) of Compound 34 prepared in Example 26, followed by heating under reflux for one hour. After evaporation of the solvent, water was added to the residue. The precipitated crystals were collected by filtration, followed by washing with water to give 0.61 g (63%) of Compound 36. The compound was recrystallized from ethanol for purification.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for one hour
  3. customAfter evaporation of the solvent, water
  4. additionwas added to the residue
  5. filtrationThe precipitated crystals were collected by filtration
  6. washby washing with water

Sources & evidence

ORD record
ord-9034049772b64b60b21c72d0b9553ad6
Source dataset
uspto-grants-1996_06
Patent number
US05527908

Reaction notes

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