Potassium Carbonate → Ethyl cyano-[[[2'-[[[(dimethylamino)methylene]amino]sulfonyl](1,1'-biphenyl)4-yl]methyl](1-oxopentyl)amino]acetate

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Reaction Steps

5.53 g of potassium carbonate and 3.33 ml of valeryl chloride were added to a solution of 1 g of the product of Stage C in 200 ml of dry acetone. After stirring for 20 hours at ambient temperature, the solution was filtered and dried. Purification was carried out by chromatography with dichloromethane-ethyl acetate 85-15 to obtain 11.6 g of the expected product as a white solid with a

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