HRID260543

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID61186

Valeryl chloride

C5H9ClO

结构：CCOC(=O)C(C#N)NCc1ccc(-c2ccccc2S(=O)(=O)N=CN(C)C)cc1

HCID54173271

未命名化合物

PRODUCTS

生成物

结构：CCCCC(=O)N(Cc1ccc(-c2ccccc2S(=O)(=O)N=CN(C)C)cc1)C(C#N)C(=O)OCC

HCID53759157

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

5.53 g of potassium carbonate and 3.33 ml of valeryl chloride were added to a solution of 1 g of the product of Stage C in 200 ml of dry acetone. After stirring for 20 hours at ambient temperature, the solution was filtered and dried. Purification was carried out by chromatography with dichloromethane-ethyl acetate 85-15 to obtain 11.6 g of the expected product as a white solid with a

WORKUP

后处理

filtrationthe solution was filtered
customdried
customPurification

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-06af633771d64b2db74903928a642b2f
来源数据集: uspto-grants-1996_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05527919
来源说明: uspto-grants-1996_06

反应 SMILES

C(=O)([O-])[O-].[K+].[K+].[C:7](Cl)(=[O:12])[CH2:8][CH2:9][CH2:10][CH3:11].[C:14]([CH:16]([NH:22][CH2:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=2[S:36]([N:39]=[CH:40][N:41]([CH3:43])[CH3:42])(=[O:38])=[O:37])=[CH:26][CH:25]=1)[C:17]([O:19][CH2:20][CH3:21])=[O:18])#[N:15]>CC(C)=O>[C:14]([CH:16]([N:22]([CH2:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=2[S:36]([N:39]=[CH:40][N:41]([CH3:42])[CH3:43])(=[O:38])=[O:37])=[CH:26][CH:25]=1)[C:7](=[O:12])[CH2:8][CH2:9][CH2:10][CH3:11])[C:17]([O:19][CH2:20][CH3:21])=[O:18])#[N:15]