Potassium Carbonate → Ethyl cyano-[[[2'-[[[(propylamino)-carbonyl]-amino]-sulfonyl]-(1,1'-biphenyl)-4-yl]-methyl]-(1-oxopentyl)-amino]-acetate

Participants

Reaction Steps

1.7 g of the product of Stage A were dissolved in 50 ml of acetone and 0.79 g of K2CO3 and 0.45 ml of valeryl chloride were added. The mixture was stirred for 6 hours at ambient temperature and the insoluble part was filtered. The filtrate was evaporated to dryness, which after purification by chromatography (eluant: dichloromethane-ethyl acetate 4-1) yielded 295 mg of the expected product with a Rf (SiO2, dichloromethane ethyl acetate 4-1)=0.30.

Provenance & Evidence