HRID260550

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID61186

Valeryl chloride

C5H9ClO

结构：CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CNC(C#N)C(=O)OCC)cc1

HCID11102546

未命名化合物

PRODUCTS

生成物

结构：CCCCC(=O)N(Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCCC)cc1)C(C#N)C(=O)OCC

HCID54501917

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

1.7 g of the product of Stage A were dissolved in 50 ml of acetone and 0.79 g of K2CO3 and 0.45 ml of valeryl chloride were added. The mixture was stirred for 6 hours at ambient temperature and the insoluble part was filtered. The filtrate was evaporated to dryness, which after purification by chromatography (eluant: dichloromethane-ethyl acetate 4-1) yielded 295 mg of the expected product with a Rf (SiO2, dichloromethane ethyl acetate 4-1)=0.30.

WORKUP

后处理

filtrationthe insoluble part was filtered
customThe filtrate was evaporated to dryness, which
customafter purification by chromatography (eluant: dichloromethane-ethyl acetate 4-1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-31a46e48db784f86828d57062d7ae3b1
来源数据集: uspto-grants-1996_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05527919
来源说明: uspto-grants-1996_06

反应 SMILES

[C:1]([CH:3]([NH:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[S:23]([NH:26][C:27]([NH:29][CH2:30][CH2:31][CH3:32])=[O:28])(=[O:25])=[O:24])=[CH:13][CH:12]=1)[C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2].C([O-])([O-])=O.[K+].[K+].[C:39](Cl)(=[O:44])[CH2:40][CH2:41][CH2:42][CH3:43]>CC(C)=O>[C:1]([CH:3]([N:9]([CH2:10][C:11]1[CH:12]=[CH:13][C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[S:23]([NH:26][C:27]([NH:29][CH2:30][CH2:31][CH3:32])=[O:28])(=[O:25])=[O:24])=[CH:15][CH:16]=1)[C:39](=[O:44])[CH2:40][CH2:41][CH2:42][CH3:43])[C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2]