HCID 22399876, compound → HCID 67742853, compound

HRID 260616Notes

Reaction equation

HRID 260616 reaction equation
[C:1]([O:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[N:23]=[CH:22][C:21]([O:24]CC3C=CC=CC=3)=[CH:20][N:19]=2)=[CH:14][CH:13]=1)(=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]>C1COCC1.[Pd]>[C:1]([O:11][C:12]1[CH:13]=[CH:14][C:15]([C:18]2[N:23]=[CH:22][C:21]([OH:24])=[CH:20][N:19]=2)=[CH:16][CH:17]=1)(=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

Participants

4

Reactant 1

HCID 22399876HCID 22399876, compound

Product 1

HCID 67742853HCID 67742853, compoundYield 91%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

3.5 g of 4-(5-benzyloxypyrimidin-2-yl)pheny1 nonanoate are dissolved in 100 ml of THF, 0.5 g of 10% Pd on activated charcoal is added, and the mixture is hydrogenated at 25° C. with stirring. The mixture is filtered through corolite, and the solvent is removed in vacuo, giving 2.5 g of 4-(5-hydroxyprimidin-2-yl)phenyl nonanoate.

Workup

  1. customis hydrogenated at 25° C.
  2. filtrationThe mixture is filtered through corolite
  3. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-ccb0d5613bd140c8907e91b0aae69af9
Source dataset
uspto-grants-1996_06
Patent number
US05529718

Reaction notes

Loading…