反应详情

First, 20.4 g of 2-isopropylphenol and 750 ml of chloroform were charged into a reaction vessel, and 80 g of tetra-n-butylammonium tribromide was added at room temperature (about 20° C.) with stirring and the mixture was stirred at room temperature for additional 24 hours. To the reaction solution, 750 ml of a saturated sodium sulfite solution was added, and the mixture was shaken vigorously to concentrate the chloroform layer. To the residue, 500 ml of diethyl ether and 500 ml of 10% hydrochloric acid were added, and the mixture was shaken vigorously. The ether layer was dried over anhydrous magnesium sulfate and concentrated to give 32 g of 4-bromo-2-isopropylphenol (yield, 100%).

1. stirringthe mixture was stirred at room temperature for additional 24 hours
2. stirringthe mixture was shaken vigorously
3. concentrationto concentrate the chloroform layer
4. additionTo the residue, 500 ml of diethyl ether and 500 ml of 10% hydrochloric acid were added
5. stirringthe mixture was shaken vigorously
6. dry with materialThe ether layer was dried over anhydrous magnesium sulfate
7. concentrationconcentrated