4-Methoxybenzyl alcohol → 4-Methoxybenzyl 4-bromobutyrate

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-methoxybenzyl alcohol and triethylamine in dichloromethane was added 4-bromobutyryl chloride at 0° C. The mixture was stirred at 0° C. for 30 minutes, and the solvent was evaporated. The residue was diluted with ethyl acetate, and the organic solution was washed with water and brine, dried over magnesium sulfate and concentrated. The concentrate was chromatographed on a silica gel column to give the object compound.

Provenance & Evidence