Ethyl 4-bromobutyrate → Ethyl 4-(3-benzyloxycarbonyl-1-indolyl)-butyrate

Participants

Reaction Conditions

Reaction Steps

A mixture of benzyl indole-3-carboxylate, ethyl 4-bromobutyrate and potassium t-butoxide in N,N-dimethylformamide was stirred at 50° C. for 4 hours. After insoluble materials were filtered off, the filtrate was diluted with ethyl acetate, and washed with diluted hydrochloric acid and water, dried over magnesium sulfate and concentrated. The concentrate was chromatographed on a silica gel column to give the object compound.

Provenance & Evidence