反应详情

温度

50 °C

A mixture of benzyl indole-3-carboxylate, ethyl 4-bromobutyrate and potassium t-butoxide in N,N-dimethylformamide was stirred at 50° C. for 4 hours. After insoluble materials were filtered off, the filtrate was diluted with ethyl acetate, and washed with diluted hydrochloric acid and water, dried over magnesium sulfate and concentrated. The concentrate was chromatographed on a silica gel column to give the object compound.

1. filtrationAfter insoluble materials were filtered off
2. additionthe filtrate was diluted with ethyl acetate
3. washwashed with diluted hydrochloric acid and water
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated
6. customThe concentrate was chromatographed on a silica gel column
7. customto give the object compound