Ethyl 4-(3-benzyloxycarbonyl-1-indolyl)-butyrate → 1-(3-Ethoxycarbonylpropyl)indole-3-carboxylic acid

HRID 260834Notes

Reaction equation

HRID 260834 reaction equation
C([O:8][C:9]([C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([CH2:20][CH2:21][CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH:12]=1)=[O:10])C1C=CC=CC=1>C(O)C.[C].[Pd]>[CH2:26]([O:25][C:23]([CH2:22][CH2:21][CH2:20][N:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]([C:9]([OH:10])=[O:8])=[CH:12]1)=[O:24])[CH3:27]

Participants

4

Reactant 1

HCID 22400494Ethyl 4-(3-benzyloxycarbonyl-1-indolyl)-butyrate

Product 1

HCID 224004721-(3-Ethoxycarbonylpropyl)indole-3-carboxylic acid

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

A mixture of ethyl 4-(3-benzyloxycarbonyl-1-indolyl)-butyrate and 10% palladium carbon in ethanol was stirred at room temperature for 1.5 hours under a hydrogen atmosphere. Removal of the catalyst and evaporation of the solvent afforded the object product.

Workup

  1. customRemoval of the catalyst and evaporation of the solvent
  2. customafforded the object product

Sources & evidence

ORD record
ord-986e4b6206814c219fb52f8130a34804
Source dataset
uspto-grants-1996_06
Patent number
US05530019

Reaction notes

Loading…