反应详情

A mixture of ethyl 4-[3-[8-(4-isobutylphenyl)undecanoyl]1-indolyl]butyrate obtained in Ex. 15 (44 mg) and 1N solution of sodium hydroxide (0.5 ml) in ethanol (1 ml) and 1,4-dioxane (2 ml) was stirred at room temperature for 3 hours. The mixture was then acidified with diluted hydrochloric acid and extracted with ethyl acetate. The organic solution was washed with water and brine, and dried over magnesium sulfate. Evaporation of the solvent afforded 4-[3-[8-(4-isobutylphenyl)-undecanoyl]1-indolyl]butyric acid as an oil (41 mg).

1. customobtained in Ex
2. extractionextracted with ethyl acetate
3. washThe organic solution was washed with water and brine
4. dry with materialdried over magnesium sulfate
5. customEvaporation of the solvent