Formanilide → 2-(1-Azabicyclo[3.3.0]octan-5-yl)ethyl-N-formylaniline

HRID 260921Notes

Reaction equation

HRID 260921 reaction equation
[CH:1]([NH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:2].Cl[CH2:11][CH2:12][C:13]12[CH2:20][CH2:19][CH2:18][N:17]1[CH2:16][CH2:15][CH2:14]2>>[N:17]12[CH2:18][CH2:19][CH2:20][C:13]1([CH2:12][CH2:11][N:3]([CH:1]=[O:2])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH2:14][CH2:15][CH2:16]2

Participants

3

Reactant 2

HCID 7671FormanilideHCID 107023655-(2-Chloroethyl)-1-azabicyclo[3.3.0]octane

Product 1

HCID 107063782-(1-Azabicyclo[3.3.0]octan-5-yl)ethyl-N-formylaniline

Procedure

The procedures described in Example 2 were repeated except that formanilide (1.80 g, 14.9 mmol) and 5-(2-chloroethyl)-1-azabicyclo[3.3.0]octane (hydrochloride, 3.43 g, 16.3 mmol ) were employed. In this case, the desired compound was obtained as a pale yellow liquid (3.39 g, 88.1 %).

Sources & evidence

ORD record
ord-adcc6dbf198a4cb18228d5848a3612aa
Source dataset
uspto-grants-1996_06
Patent number
US05530138

Reaction notes

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