反应详情

62 g of NaBH4 are initially introduced into 320 ml of dioxane. A solution of 319 g of 5-chloro-2,3,4-trifluorobenzoyl fluoride in 640 ml of dioxane is run into this, at the reflux temperature, over the course of 6 hours. After boiling under reflux for a further hour, the mixture is poured onto ice, the pH is adjusted to 1 with dilute hydrochloric acid, and the organic phase is extracted with methylene chloride and then distilled: 261 g of 2,3,4-trifluoro-5-chlorobenzyl alcohol of boiling point 109° C./12 mbar are obtained.

1. customover the course of 6 hours
2. temperatureunder reflux for a further hour
3. additionthe mixture is poured onto ice
4. extractionthe organic phase is extracted with methylene chloride
5. distillationdistilled