Hydrochloric Acid → HCID 20395796, compound

HRID 261023Notes

Reaction equation

HRID 261023 reaction equation
[ClH:1].N1C=CC=CC=1.Cl.[C:9]([C:11]1[S:12][C:13](=[NH:28])[N:14]2[CH2:23][CH2:22][C:21]3[C:16](=[CH:17][C:18]([O:26]C)=[C:19]([O:24]C)[CH:20]=3)[C:15]=12)#[N:10].Cl>O>[OH2:24].[OH2:24].[ClH:1].[C:9]([C:11]1[S:12][C:13](=[NH:28])[N:14]2[CH2:23][CH2:22][C:21]3[C:16](=[CH:17][C:18]([OH:26])=[C:19]([OH:24])[CH:20]=3)[C:15]=12)#[N:10]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10176127Pyridinium chlorideHCID 20395794HCID 20395794, compound

Product 1

HCID 20395796HCID 20395796, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

20.0 g. of pyridine hydrochloride are added to 6.0 g. of 1-cyano-3-imino-8,9-dimethoxy-3,4,5,6-tetrahydro-1,3-thiazolo[4,3-a]isoquinoline hydrochloride, and the mixture is kept for 2 hours in an oil bath of 210°-220° C. The mixture is cooled and a mixture of 6 ml. of concentrated hydrochloric acid and 14 ml. of water is added. 5.2 g. of crystalline 1-cyano-3-imino-8,9-dihydroxy-3,4,5,6-tetrahydro-1,3-thiazolo[4,3-a]isoquinoline hydrochloride dihydrate are obtained; m.p.: gradually decomposes from 280° C. (after recryltallization from hot water).

Workup

  1. temperatureThe mixture is cooled
  2. additiona mixture of 6 ml

Sources & evidence

ORD record
ord-7d939c20d6574384a7e03742b0a9f821
Source dataset
uspto-grants-1979_08
Patent number
US04163786

Reaction notes

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