Benzoyl chloride → 6-Chloro-2-(4-benzoyl-1-piperazinyl)-pyrazine

HRID 261063Notes

Reaction equation

HRID 261063 reaction equation
Cl.[Cl:2][C:3]1[N:8]=[C:7]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:6]=[N:5][CH:4]=1.[C:15](Cl)(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(=O)([O-])[O-].[Na+].[Na+]>[Cl:2][C:3]1[N:8]=[C:7]([N:9]2[CH2:10][CH2:11][N:12]([C:15](=[O:22])[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:13][CH2:14]2)[CH:6]=[N:5][CH:4]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 198421MK-212 hydrochloride

Product 1

HCID 203960136-Chloro-2-(4-benzoyl-1-piperazinyl)-pyrazine

Reagents, catalysts & solvents 1

HCID 10340Sodium CarbonateSolvent

Procedure

Using a procedure similar to that of Example 4, 2.35 g (0.010 mole) of 6-chloro-2-(1-piperazinyl)-pyrazine hydrochloride is dissolved in 20 ml saturated aqueous sodium carbonate solution and treated with 2 ml benzoyl chloride. After stirring 10 minutes at room temperature, the crude product is extracted with toluene and recrystallized from n-butyl-chloride-cyclohexane (charcoal treatment) to give colorless crystals of the title compound, mp 104.5°-105° C.

Workup

  1. extractionthe crude product is extracted with toluene
  2. customrecrystallized from n-butyl-chloride-cyclohexane (charcoal treatment)

Sources & evidence

ORD record
ord-4bc016454c764d62ad846e3cec003d14
Source dataset
uspto-grants-1979_08
Patent number
US04163849

Reaction notes

Loading…