Benzoyl chloride → 6-Chloro-2-(4-benzoyl-1-piperazinyl)-pyrazine

Participants

Reaction Steps

Using a procedure similar to that of Example 4, 2.35 g (0.010 mole) of 6-chloro-2-(1-piperazinyl)-pyrazine hydrochloride is dissolved in 20 ml saturated aqueous sodium carbonate solution and treated with 2 ml benzoyl chloride. After stirring 10 minutes at room temperature, the crude product is extracted with toluene and recrystallized from n-butyl-chloride-cyclohexane (charcoal treatment) to give colorless crystals of the title compound, mp 104.5°-105° C.

Provenance & Evidence